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Rheumatologie und Immunologie

Research Rheumatology and Immunology Internal Medicine University departments Medical University of Graz

Research team Matteo Villa

Our research focusses on how immune cells infiltrating inflamed peripheral tissues (such as the joints during Rheumatoid Arthritis) sense and adapt their transcriptional and metabolic profiles to the surrounding environment. We investigate questions that are clinically relevant, combining the analysis of human samples with state-of-the-art techniques such as flow cytometry, single cell transcriptomics, metabolic profiling and CRISPR-Cas9 gene editing.

Contact

Matteo Villa

T: +43 316 385 17779

E: matteo.villa(at)medunigraz.at

Research profile

Labor

Our goal

We aim to identify the molecular and cellular mechanisms that mediate the adaptation of immune cells to peripheral tissues. These may become novel targets to prevent the infiltration of immune cells in peripheral tissues, and to restore the physiological function of tissues.

Labor

Our projects

Understanding the metabolic adaptation of immune cells to the joint environment in rheumatoid arthritis.
The metabolic cross-talk of immune cells and fibroblasts in the rheumatoid arthritis synovium.

Team

Members

Collaboration partners