The immune response is a dynamic process. During autoimmune and autoinflammatory diseases, immune cells get activated and migrate to sides of inflammation – often peripheral tissues, such as the joints, skin, or the lung. We want to understand how immune cells sense these different environments, and how this influences immune cell function. We also study the interaction of different immune cell types, such as T cells, B cells and macrophages with each other but also with tissue-resident cells such as fibroblasts. A better understanding of how these interactions underscore inflammation and autoimmunity in peripheral tissues is needed for the development of personalized treatment options.
